Cell[IF:66.85]
① 纳入70对母婴，对孕晚期至孩子1岁期间的母婴肠道菌群和代谢组进行纵向整合分析；
② 发现一种新的垂直传递模式：一些没传递给婴儿的母亲肠菌（如某些拟杆菌目物种）通过可移动遗传元件向婴儿肠菌传递基因，从而塑造婴儿菌群的结构和功能（如利用HMO的能力）；
③ 孕期菌群和代谢组变化（如类固醇化合物增多）可影响母体代谢健康（如糖耐受损伤），婴儿肠道代谢组多样性不如母亲，但存在大量的婴儿独有的代谢物和肠菌-代谢物关联；
④ 饮食（母乳、普通配方奶、水解配方奶）可调节婴儿的代谢组谱和免疫系统成熟。
Mobile genetic elements from the maternal microbiome shape infant gut microbial assembly and metabolism
12-22, doi: 10.1016/j.cell.2022.11.023
【主编评语】生命早期的肠道菌群组成和功能受多种因素的影响。其中，源自母亲的微生物垂直传递是孩子早期肠道菌群的重要来源。Cell最新发表了来自Broad研究所Ramnik Xavier团队的研究，发现了一种新的母婴垂直传递模式，即未在婴儿中定植的母体肠菌能通过水平基因转移，影响婴儿肠道菌群的组装和代谢潜力。
Mobile genetic elements from the maternal microbiome shape infant gut microbial assembly and metabolism
来自母体微生物组的可移动遗传元件塑造婴儿肠道微生物组装和代谢
10.1016/j.cell.2022.11.023
12-22, Article
Abstract:
The perinatal period represents a critical window for cognitive and immune system development, promoted by maternal and infant gut microbiomes and their metabolites. Here, we tracked the co-development of microbiomes and metabolomes from late pregnancy to 1 year of age using longitudinal multi-omics data from a cohort of 70 mother-infant dyads. We discovered large-scale mother-to-infant interspecies transfer of mobile genetic elements, frequently involving genes associated with diet-related adaptations. Infant gut metabolomes were less diverse than maternal but featured hundreds of unique metabolites and microbe-metabolite associations not detected in mothers. Metabolomes and serum cytokine signatures of infants who received regular—but not extensively hydrolyzed—formula were distinct from those of exclusively breastfed infants. Taken together, our integrative analysis expands the concept of vertical transmission of the gut microbiome and provides original insights into the development of maternal and infant microbiomes and metabolomes during late pregnancy and early life.
First Authors:
Tommi Vatanen,Karolina S Jabbar
Correspondence Authors:
Ramnik J Xavier
All Authors:
Tommi Vatanen,Karolina S Jabbar,Terhi Ruohtula,Jarno Honkanen,Julian Avila-Pacheco,Heli Siljander,Martin Stražar,Sami Oikarinen,Heikki Hyöty,Jorma Ilonen,Caroline M Mitchell,Moran Yassour,Suvi M Virtanen,Clary B Clish,Damian R Plichta,Hera Vlamakis,Mikael Knip,Ramnik J Xavier
